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開心鬼（黃百鳴）轉世投胎，搖身變作某女子中學教師，在他班上，幾名愛捉弄人的調皮女生，戴卓儀（袁潔瑩）、MAY（羅美薇）和姚瓊（陳家玲），成立了以整人為樂的“卑鄙會”，開心鬼是她們最愛拿來開玩笑的對象。
They’re back! The Warner brothers, Yakko and Wakko, and the Warner sister Dot, have a great time wreaking havoc and mayhem in the lives of everyone they meet. After returning to their beloved home, the Warner Bros. water tower, the siblings waste no time in causing chaos and comic confusion as they run loose through the studio, turning the world into their personal playground. Joining Yakko, Wakko and Dot, fan-favorite characters Pinky and the Brain also return to continue their quest for world domination.
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